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Literature Highlights Issue 1 April 2024: N-Containing Heterocycles

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Neurodegeneration

Neuroscience

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Assessing the effect of candidate drugs on the phagocytic activity of human iPSC-derived Microglia

Spatial Biology

BioAnalysis

Bioanalysis for Biomarkers

New Therapeutic Modalities

Image Analysis

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Novel Assays to enhance Spatial Biomarker Discovery and development

Immunology

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Epithelial to Mesenchymal Transition (EMT) can be driven by macrophages through multiple signalling pathways

Chemistry

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Investigating Polymorph Control of a potential drug substance

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Case Study - GMP Manufacture of CLS7001

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Lead Identification

Computer Aided Drug Discovery

Structure-based Drug Design

Medicinal Chemistry

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Development of a selective WEE1 inhibitor

Chemistry

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One-pot borylation/Suzuki-Miyaura sp2–sp3 cross-coupling

Hit Generation

Virtual Screening

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Combining AI-driven virtual screening with biophysics to identify novel BRPF1b inhibitors

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