Oligonucleotides

We excel at providing tailored solutions to get your oligonucleotide through the discovery and development process. From early-stage screening with optimized assays to bioanalytical methods to monitor the quality and functionality of your oligonucleotide we can be your partner from concept to clinic.

• ‍Assay development and candidate screening‍
• Mechanism of action studies‍
• Pharmacokinetic and safety assessment
• Robust characterization including oligonucleotides delivered in nanoparticles
• Potency, stability, formulation and comparability testing
• Support the preparation of IND or IMPD documents for the submission of a clinical study
  

Tailored ADME & DMPK assays for oligonucleotide therapeutic development

To ensure the safety and efficacy of oligonucleotide therapeutics, precise pharmacodynamic, pharmacokinetic and immunogenicity assessment is crucial. We provide customized assays to provide accurate and specific data tailored to the unique characteristics of your oligonucleotide therapeutic, as well as specialized assays for ADME to assess the therapeutics biodistribution, stability, and clearance.

Oligonucleotide therapeutics in drug discovery and development

Oligonucleotides are short DNA or RNA sequences used in drug discovery for targeting specific genes or proteins involved in diseases. They function as antisense therapies, binding to messenger RNA (mRNA) to prevent the production of harmful proteins. There are several classes of oligonucleotides including small interfering RNA (siRNA) and microRNA (miRNA) which are used to silence or regulate gene expression.

Another class of single-stranded DNA/RNA are called aptamers, that can bind to specific targets, such as proteins or small molecules, with high affinity and specificity. They function similarly to antibodies but offer advantages like easier synthesis, lower immunogenicity, and greater stability, making them useful in therapeutics, diagnostics, and drug delivery. This precision makes oligonucleotide-based drugs valuable for treating genetic disorders, cancers, and viral infections.

Why not talk to us today to get a clear insight into how we can partner with you to advance your oligonucleotide therapeutic into the clinic. Our advice is free and could help you accelerate your program whilst reducing your costs. Our typical project timeline is half that of the industry average.