Biophysics

Biophysics integrates the principles of physics and biology to explore biological systems at the molecular and cellular levels. It is used to understand the physical properties and mechanisms underlying biological processes, including molecular structures, dynamics and interactions that drive biological functions.

Both biophysical characterization and interaction analysis play crucial roles in modern drug discovery, offering invaluable insights into the behavior and properties of diverse therapeutic modalities. Our biophysical assays are regularly incorporated into our integrated drug discovery projects, working in tandem with biochemical or cell-based assays to quickly return binding data to our ADMET/DMPK and medicinal chemistry colleagues.  

‍Modality-agnostic biophysical analysis 

Our biophysical sciences team uses state-of-the-art tools and a deep understanding of biophysical methodologies to investigate binding interactions, molecular stability and aggregation propensity, all of which are essential for evaluating drug-target relationships in a wide range of therapeutic entities including small molecules, oligonucleotides, TPDs (PROTACS and molecular glues), peptides, proteins, antibodies, and various viral- and non-viral vectors. 

The team not only offers precise data interpretation but also customized guidance on a biophysics cascade strategy and complementary approaches. Our industry-leading turnaround times ensures a rapid transition from early-stage discovery to candidate optimization, advancing our clients’ projects with unparalleled precision, efficiency, and scientific rigor. 

Comprehensive suite of biophysical technologies  

Our high-end biophysics technology platform expediates the hit finding, hit confirmation, hit-to-lead and lead optimization stages in drug discovery, as well as providing a full mechanistic, kinetic, thermodynamic and structural profile for your novel compounds. The biophysical methods we have available can be applied to a wide variety of molecular interactions from fragment-protein, small molecule-oligonucleotide, peptide-protein to protein-protein, antibody-antigen and nanobody interactions. 

With our extensive suite of characterization tools, we are also able to ensure that we are using high quality protein reagents in our screening assays, as well as supporting product development processes with precision and efficiency. Leveraging extensive experience across diverse product types—such as proteins, monoclonal antibodies, vaccines, PEGylated proteins, antibody-drug conjugates, oligonucleotides, glycoproteins, and biosimilars—we employ a broad range of advanced biophysical technologies to provide comprehensive and detailed insights. For example, we can examine secondary and tertiary structure, aggregation, oligomerization, and degradation of your drug substance as well as support formulation development, with forced-degradation and biologics characterization in different buffers and in the presence of additives/excipients of interest. 

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