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Biophysical Characterization
Advance your biological candidate from discovery to clinic
Biophysical characterization plays a crucial role in the drug discovery process of biologics by offering invaluable insights into the properties of diverse therapeutic modalities. Our biophysical sciences team uses state-of-the-art tools and expertise to support the development of a wide range of biological therapeutic entities, including oligonucleotides, peptides, proteins, antibodies, antibody fragments, ADCs, TPD (PROTACs and molecular glues), and various viral- and non-viral vectors.
Advancing drug discovery through biophysical insights
By leveraging our comprehensive biophysical characterization capabilities, we help our partners:
- Accelerate lead optimization: Rapidly identify and prioritize promising candidates based on their biophysical properties, thereby streamlining the drug discovery process
- Optimize biologic stability: Assess and enhance the stability of therapeutic candidates under various environmental conditions, ensuring longer shelf-life and maintained efficacy
- Improve formulation strategies: Develop stable formulations that preserve the activity of complex biologics and delivery systems
- Support regulatory compliance: Generate robust data packages that align with regulatory requirements for diverse therapeutic modalities
- Mitigate development risks: Early identification of potential issues related to aggregation or misfolding allows for timely interventions, reducing the risk of product failure during clinical development
Our extensive expertise and advanced instrumentation, means the biophysical sciences team can design custom workflows to support effective translation of diverse therapeutic modalities from early biologics discovery to candidate selection. A comprehensive approach ensures thorough characterization, enabling informed decision-making throughout the drug discovery process.
Comprehensive biophysical characterization services
We utilize orthogonal approaches to provide a holistic view of your therapeutic candidates. This allow us to assess critical quality attributes (CQAs) that are essential for therapeutic efficacy, such as:
Structural Analysis
- Secondary and tertiary structure determination
- Conformational stability assessment
- Molecular weight and size distribution analysis
Stability and Formulation Assessment
- Thermal and colloidal stability assessments
- Aggregation propensity studies
- Formulation optimization support
Tailored solutions for diverse therapeutic modalities
Our modality and disease-agnostic approach allows us to provide comprehensive biophysical characterization support for a wide range of therapeutic modalities, including:
Peptides, Proteins, Antibodies, ADCs, TPDs and oligonucleotides
- Secondary and tertiary structure analysis
- Stability assessments under various conditions
- Binding specificity and off-target interaction studies
- Epitope mapping
Viral and Non-viral Vectors including LNPs
- Particle size and distribution analysis
- Surface charge measurements
- Payload encapsulation efficiency determination
- Vector-target cell interaction studies
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