Biochemical Assays

The right foundation for your screening cascade

We have extensive experience developing, validating and using biochemical assays for a wide range of target types including enzymes, GPCRs, ion channels, nuclear receptors and epigenetic targets. Whether commercially available or customized, we deliver robust, cost effective screening assays that meet your project needs.

Biochemical assays are often used as the primary assay in a drug discovery screening cascade due to their accessibility, cost-effectiveness, scalability, and robustness.

  • Our suite of technologies supports rapid, high throughput analysis and includes: HTRF, TR-FRET, NanoBRET, AlphaLISA, FLIPR assays, GLO assays, rapid Westerns using Jess systems and Fluorescence Polarization (FP)
  • Our screening methods can analyze large compound libraries, enabling you to quickly identify molecules that exhibit the correct activity profile against the target biomolecule
  • We have invested heavily in state-of-the-art liquid handling systems to ensure rapid and consistent reagent addition to microplates of 6 to 1536-well formats

Why work with us for your biochemical screening?

  • We have the experience to overcome complex problems where other may fail, acquiring high-quality hits against even the most challenging targets
  • We work closely alongside our clients using our knowledge and experience to interpret complex data and deliver those important results when required
  • Whether commercially available or customized, we deliver robust, cost effective screening assays that meet your project needs

View our poster Development of a selective WEE1 inhibitor to find out more about the approach we take.

Biochemical assay example from WEE1 biochemical inhibition poster
Profiling a Concept Life Sciences’ analogue versus AZD1775. Compound effects on (A) WEE1 biochemical inhibition, (B) PLK1 biochemical inhibition, (C) WEE1 cellular activity (pCDK1 in MDA-MB-231), (D) cellular viability (MDA-MB-231).

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