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Biochemical Assays

The right foundation for your screening cascade

Biochemical assays are often used as the primary assay in a drug discovery screening cascade due to their accessibility, cost-effectiveness, scalability, and robustness.

  • We have extensive experience developing, validating and using biochemical assays for a wide range of target types including enzymes, GPCRs, ion channels, nuclear receptors and epigenetic targets
  • Our suite of technologies supports rapid, high throughput analysis and includes: HTRF, TR-FRET, NanoBRET, AlphaLISA, FLIPR assays, GLO assays, rapid Westerns using Jess systems and Fluorescence Polarization (FP)
  • Our screening methods can analyze large compound libraries, enabling you to quickly identify molecules that exhibit the correct activity profile against the target biomolecule
  • We have invested heavily in state-of-the-art liquid handling systems to ensure rapid and consistent reagent addition to microplates of 6 to 1536-well formats

Why work with us for your biochemical screening?

  • Whether commercially available or customized, we deliver robust, cost effective screening assays that meet your project needs
  • We have the experience to overcome complex problems where other may fail, acquiring high-quality hits against even the most challenging targets
  • We work closely alongside our clients using our knowledge and experience to interpret complex data and deliver those important results when required
Image off WEE1 poster
Profiling a Concept Life Sciences’ analogue versus AZD1775. Compound effects on (A) WEE1 biochemical inhibition, (B) PLK1 biochemical inhibition, (C) WEE1 cellular activity (pCDK1 in MDA-MB-231), (D) cellular viability (MDA-MB-231).

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