Assay Development

Our assay development service is tailored to suit the demands of every drug discovery project, each with its own unique requirements. Whether you are looking for cell-based, biophysical or biochemical assays our biologists can meet your needs.

We work with you to design and develop the most suitable assay for your project adding value by:

• Ensuring assays are fit for purpose every step of the way. Whether we use pre-validated or customized assays, the intention is to use the most appropriate assay which will address the most pressing questions for your projects
• Calling on the expertise within the team, who have decades of troubleshooting experience ensuring there are minimal delays to project progression as we increase the robustness of your assays 
• Being flexible enough to offer the level of service you require from individual assays through to screening cascades. Our understanding of when an assay is ready to progress from development to enter the regular screening cascade saves both project time and money as we use the assays for SAR and hit-to-lead activities

Customized assay development and pre-validated assays

Reliable, reproducible assays are essential for making well informed decisions about the next steps in your drug discovery project. 

Customized assay development is where the collective experience and expertise of the team can have a significant impact on your project. When developing a custom assay there are many factors we consider such as:

• A target based or phenotypic based approach
• Plate format and type
• Assay volume
• Assay homogeneity
• Delivery of statistically valid and reproducible data

Strict quality controls and validation techniques are employed to ensure that the assay is fit for purpose and advances your project to the next key milestone.

We also recognize when a pre-validated assay is suitable and can offer a time and cost-effective option versus custom assay development. Our poster on Development of a selective WEE1 inhibitor illustrates a project we undertook using a number of pre-validated kinase assays.

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