Tier 2 – Discovery+

Our DMPK experts help steer your project to success with a clear insight into the pharmacokinetics of your therapeutic. The team develop impactful in vivo PK studies before generating and interpreting data that helps you make informed decisions about the next stage of your project.

• Offers early identification of potential issues, our knowledgeable team will provide method development ensuring the most efficient route possible
• We provide you with a comprehensive and concise summary document containing analytical summary and comments, methodology, raw data, working solution scheme and representative chromatography

‍H3: About our Tier 2 – Discovery+ bioanalytical services

‍Discovery+ builds upon our tier 1 - Discovery service by incorporating method development to address any issues be encountered during the optimization process or following an initial sample analysis. Before initiating of any method development, identified issues are discussed with the client to create a clear plan that minimizes the allocation of method development hours, thus reducing cost and time. As with all tiers, reporting options are available, from simple data tables to formal written data reports, and we have the flexible alongside our standard templates, we have the capacity to tailor these documents to your requirements.

What does Tier 2 – Discovery+ consist of:

• Compound optimization (MS and LC), 
• Sample extraction, 
• Inclusion of generic internal standards or optimisation of analogues/stable labels if available or provided
• Data processing (concentration data, PK parameter interpretation available at request)
• Reporting 
• Method development allocation to service the aforementioned items (maximum allocation of 5 days).

Find out more about our the other tiers

• PK screening: a cost-effective option for optimization and compatibility testing of your compound, using minimal material and reducing animal usage
• Tier 2 - Discovery+: enhanced bioanalysis with method development for your discovery projects, prioritizing specificity, speed and high-quality results
• Tier 3 - Discovery+ Customized: is a customized bioanalytical service for clients needing tailored methods and willing to invest time and resources into method development and robustness testing
• Tier 4 - Scientific Validation: supports in vitro projects and early-stage non-regulated/non-clinical/clinical analyses, offering method validation in addition to standard services, with separate studies for development, validation, and analysis, and optional QA audits‍
• Tier 5 - Full Validation: supports non-clinical GLP and clinical GCP projects, conducting validations per industry guidelines with separate method development, validation, and analysis studies, including optional QA audits, long-term stability assessments, and incurred sample reanalysis (ISR) for pivotal trials

Find out how we can help you rapidly evaluate the PK of your therapeutic and have a confidential discussion with our experts about your project needs.