ProDrugs

Whether it’s type I (intracellular) or Type II (extracellular) prodrug development can present several challenges. Utilizing the experience of our expert medicinal chemistry team ensures we can help you overcome these and achieve your project goals.

• Designing a prodrug strategy and rapidly constructing a library of derivatives for preparation which will help accelerate your project development and reduce costs
• Developing a new approach to your prodrug strategy by using novel ProTides
• Helping you translate your prodrug candidate into the clinic

Synthetic prodrug development‍

Pursuing a prodrug strategy potentially has noticeable drawbacks for your synthetic chemistry operations. Prodrug structures can be designed with built-in chemical liabilities, resulting in the development of small molecules which are difficult to synthesize and purify due to inherent stability issues.

In addition, development of specific prodrug formats can give rise to charged compounds which are difficult to purify and analyze, and others which require specific expertise to construct.

Our team use their collective experience to meet these challenges through the creation of a prodrug development strategy and derivatives library for preparation. The use of novel ProTides offers a new approach to your prodrug strategy with the team able to synthesize, purify and characterize these compounds.

Investigating the ADME properties of prodrugs

The growing sophistication of prodrug technology means that it is no longer a last attempt to improve cell permeability. Rather, it’s a tool to overcome a broad range of challenges in drug discovery including drug distribution and improvements in patient compliance by simply enhancing taste.

However, early understanding of the ADME properties is still key in prodrug development due to their ability to enhance the solubility, permeability or metabolic stability of compounds. With a 5-day turnaround for our in vitro ADME and DMPK assays we are able to quickly understand how to effectively feed important data into the design-make-test cycle.

Contact us today for a confidential discussion about how we can help you advance your Prodrug projects whilst reducing the time and cost it takes to get your therapeutic to the clinic.