Direct-to-Biology (D2B)

Streamlining the drug discovery process by going direct-to-biology (D2B), allows you to rapidly explore chemical space, identify hits and validate biological activity quickly. What would previously take weeks or even months can now happen within days.

This collaborative approach also enables you to obtain preliminary ADMET /DMPK data early, therefore gaining a more comprehensive picture of a compound’s properties at a much earlier stage in the drug discovery process.

Why Choose Direct-to-Biology (D2B) for Drug Discovery?

• Faster Results: D2B cuts out purification steps, allowing immediate testing after synthesis. This speeds up the hit finding stage from weeks to days
• Rapid Optimization: Get real-time feedback with quick design, synthesis, and biological screening cycles, plus continuously refine compounds for optimal performance
• Cost-Efficient: Fewer steps mean fewer resources. D2B reduces both material and time costs, providing a more economical pathway to discovery
• Higher-throughput Capability: Screen thousands of compounds simultaneously, increasing the chance of finding the right biological match faster
• Flexible Across Targets: Suitable for various targets, from small molecules to covalent inhibitors, D2B adapts to your specific therapeutic focus

Contact us to see how our D2B services can help you reach your next key milestone!

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Direct-to-Biology Workflow

Our concise D2B approach is customized and optimized to suit your project’s needs before the workflow commences. Once optimized you can obtain hit finding results in as little as seven days, depending on the chemistry and assays required. With hit finding accelerated, key decision points occur earlier than when using traditional methodologies, saving you both time and money.

This process means:

• Plates of compounds can be synthesized and screened
• Data is easily visible through a heat-map overview indicating the quality of the plate
• Hits can be identified and preliminary ADME / DMPK data can be obtained

By combining plate-based chemistry and our ability to quickly complete biological screening, results can be turned around swiftly.

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Direct-to-Biology (D2B) at Concept Life Sciences

Plate-based Chemistry

• Compound library design
• Accelerated compound synthesis
• SAR (structure-activity relationship) analysis based on biological feedback
• Enhances efficiency and sustainability of reactions

All achieved by our expert team of synthetic  and computational chemists. They focus on rapidly modifying and optimizing leads to improve both potency and drug-like properties (solubility, stability).

Quick Screening Capabilities

• Tailored biological assays for specific therapeutic targets
• Integration of advanced biochemical, biophysical, and cell-based assays
• Enables the early understanding of mechanism of action (MoA)
• Prompt DMPK / ADMET properties for optimization  
• Fast turnaround on identifying and optimizing hits into viable lead candidates

Project and Data Management

Our direct-to-biology services benefit from a strong project management team with deep expertise in medicinal chemistry, and biology ensuring scientific excellence at every stage. Our experienced project management team ensures:

• Seamless Cross-Functional Collaboration: Our team coordinates chemistry, biology, and ADME/DMPK activities for a streamlined approach, keeping all stakeholders aligned and focused on your drug discovery goals
• Efficient Timeline & Risk Management: We set clear milestones within the project team and address potential risks early, ensuring timely delivery of key results while maintaining the flexibility to adapt to new data or challenges
• Transparent Communication: Regular, clear updates and actionable insights keep you informed
• Robust Data Management & Decision-Making: Leverage data-driven insights to prioritize tasks and make informed decisions. Our streamlined data management ensures real-time access to critical project data, keeping all teams aligned and progressing the drug discovery program

Download our poster Accelerating PROTAC Development: A Direct-to-Biology Approach for Rapid Synthesis and Profiling of PROTACS.

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