Custom Peptide Synthesis

Peptides are at the forefront of modern drug discovery, offering high specificity, potency fora diverse range of therapeutic applications. Our custom peptide synthesis services provide end-to-end support, from design and synthesis to advanced characterization and optimization, ensuring high-quality peptides tailored to your research and development needs.

We provide:

• End-to-End chemistry support – From initial hit to optimized peptides, we ensure your synthetic route fits the stage you are in and prepares you for clinical investigations
• State-of-the-art facilities & technologies – Leveraging the latest advancements in peptide design, synthesis, analytical and purification techniques to move your program forward
• Experienced scientific team – Dedicated experts with a track record of success in peptide drug discovery and development
• Customized solutions – Tailored approaches to meet specific project requirements and business models, including automated and manual solid-phase peptide synthesis (SPPS)

Expertise in Peptide Chemistry & Synthesis

With extensive experience in custom peptide synthesis, our team specializes in synthesizing a wide range of peptides, including:

• Linear peptides – Designing peptides with enhanced stability and bioactivity. We adapt synthetic routes and reaction conditions to each peptide sequence.
• Cyclic peptides – Using a range of cyclization techniques: 
  
  • Stapled
  • Click chemistry 
  • Disulfide and thioether isosteres
  • Including Bi- and Tri-cyclic peptides
• Peptoids – For increasing the stability and masking metabolic soft spots
• Un-natural / non-canonical amino Acid incorporation – Custom modifications to improve stability, selectivity, and function. We constantly expend our library of amino acid building blocks:
  
  • Proprietary library of >250 canonical and non-canonical amino acids
  • Development of innovative synthetic techniques to access novel amino acids
• Peptide-drug conjugates – Attaching macrocyclic peptides to warheads using adapted linker structures and conjugation technologies.
• Synthesizes peptide-based linkers - Including the ubiquitous valine-citrulline dipeptide and attaching them to a diverse array of payloads for subsequent antibody bioconjugation for ADC discovery.

Cutting edge CADD technologies for peptide design

We use state of the art commercial software Schrӧdinger at the forefront of our modelling routines , for lineat and macrocyclic peptides. 

Our peptide modelling services include: 

• 2D-Sequence to 3D-Structural assignment
• Combinatorial enumeration
• Physicochemical predictions
• Site-directed mutation (natural/non-natural amino acids)
• Molecular Docking + Free-energy Optimization
• Molecular Dynamics
• Advanced computational hardware
  • Our CPU/GPU hardware accelerates intensive simulations, shedding light on factors like peptide aggregation and tertiary structure rearrangement.

These capabilities allow us to make rapid, data-driven decisions in peptide iterations, shortening timelines and reduce overall drug development cost.

Purification and analysis

Dedicated team purification and analytical chemists

• Expedite the rapid turnaround of compounds, enabling high throughput projects 
• Allowing chemists on the project to concentrate on synthesizing new targets without being distracted by complicated purification work

Open access UPLC-MS systems

• Equipped with UV, MS and ELS detectors, enables us to tailor our analytical methods for each project
• Enables optimization of purity profiles and tracking of reaction components/by-products 
• Supporting a wide range of molecule types – from small molecules to peptides of up to 5,000 Da. 

This comprehensive approach results in higher levels of understanding and greater confidence in quality of synthesized peptides.

Our Peptide Discovery Engine

This integrated peptide drug discovery service unites:

• Advanced in silico modelling
• Cutting-edge chemistry
• Tailored ADME profiling
• Rigorous biological assessments 
• Adapted toxicology read outs

Streamlining the journey from hit identification to lead nomination.

Find out more about how we combine our services for an optimum integrated approach to peptide drug discovery here.