Medicinal Chemistry

Your drug discovery project is unique. We understand and develop customized medicinal chemistry strategies adapted to each therapeutic area, mechanism of action, mode of delivery, business model, and across the competitive landscape to identify a high-quality drug candidate.

Our medicinal chemists have an in-depth understanding of all scientific disciplines underpinning the drug discovery process and work closely with synthetic and computational chemists, biologists and DMPK scientists in a multidisciplinary team to deliver your project goals.

In depth expertise with medicinal chemistry services adapted to your needs

Our medicinal chemists have built a strong track record of developing high-value clinical assets across therapeutic areas and target classes:

• Named inventors on > 30 patents
• Authored > 50 peers reviewed articles
• Accelerated > 300 clients’ programs
• Enabled the discovery of > 20 clinical candidates and 4 marketed drugs

We understand the importance of delivering against the project progression criteria and work closely with our partners to provide medicinal chemistry solutions adapted to your needs:

• Standalone medicinal chemistry: An extension to your research team, we manage decision-making processes and activities to accelerate the delivery of your drug discovery program
• Integrated drug discovery: As part of a fully integrated drug discovery service, adding maximal value to your project as a true “one-stop-shop"
• Consultancy: We analyze literature and proprietary Structure Activity Relationships (SAR) to support defined work packages such as competitive landscape review or licensing activities

Scientific excellence empowered by cutting-edge technologies

We accelerate the hit optimization process with lean Design-Make-Test-Analyze cycles and steer your project throughout the drug discovery process by:

• Establishing a drug discovery strategy and a critical path
• Designing a purposeful screening cascade
• Formulating and testing SAR hypotheses using appropriate design strategies
• Applying technologies such as Sparse Array Design, CNS-MPO and Matched Molecular Pair analysis
• Developing synthetic routes to unchartered chemical spaces, thus enabling the comprehensive exploration of SAR and generation of appropriate Intellectual Property
• Harnessing the power of computational modelling, cheminformatics and Machine Learning to efficiently optimize chemical series
• Monitoring both competitive landscape and progress against Lead Candidate criteria

Our medicinal chemistry expertise span classic and new therapeutic modalities such as PROTACs, ADCs, peptides and nucleotides. Using our know-how, we anticipate hurdles associated with each modality and develop adapted solutions leading to clinical success.

Our integrated drug discovery informatics platform enables our scientists to efficiently share ideas across scientific disciplines, effortlessly monitor project progression and promptly communicate data with you. This means our medicinal chemists are agile and can pave the leanest way to the clinic for each of your projects.