Peptides

From creating libraries of small peptide linkers to developing complex cyclic peptides, our peptide chemistry ensures you get the most out of your peptide drug discovery project.

Custom peptide synthesis

Utilizing our automated solid phase peptide synthesizer, our peptide chemists can synthesize four peptides concurrently, providing swift delivery of crude peptides. Alternatively, traditional solution phase peptide synthesis with modern amide coupling reagents can play a role in short peptide linker chemistry.

Late-stage modifications such as cyclization, are often a complex yet important part of peptide drug discovery. With multiple options for cyclization, we can use our experience to develop the best possible route for success in your synthesis.

Peptides in drug discovery

The last couple of decades have witnessed a huge growth in the use of peptides in drug discovery.  Part of this growth is due to the mindset of the modern drug hunter, who no longer views peptides simply as chemical probes to investigate biological systems, but rather, as a viable strategy to develop a therapy. The recent development of GLP-1 therapies are already having a positive effect on human metabolic health.

A second reason for a renaissance in peptides is because of visionaries who have pioneered their use in novel therapeutic modalities such as linkers in antibody drug conjugates and targeted protein degraders, and as a technology to selectively deliver payloads to certain cell types.

We have long played a key role in helping our clients progress their peptides from concept to clinic by:

• Synthesizing libraries of peptide-based linkers, including the ubiquitous valine-citrulline dipeptide and attaching them to a diverse array of payloads for subsequent antibody bioconjugation
• Attaching macrocyclic peptides to warheads to prepare peptide-drug conjugates
• Developing syntheses of complex unnatural α-amino acids utilizing both modern & traditional approaches and incorporating them into peptides

Looking for a trusted partner to help expedite your peptide-based therapy? We’d love to help.