Tier 1 – Discovery

Our DMPK experts help steer your project to success with a clear insight into the pharmacokinetics of your therapeutic. The team develop impactful in vivo PK studies before generating and interpreting data that helps you make informed decisions about the next stage of your project.

• Our Discovery service is our entry level provision for your bioanalytical needs, including in-life study organization and consultancy, if required 
• Our Tier 1 – Discovery, is the prefect follow on from the PK screen or suitable for familiar chemical series
• We provide you with a comprehensive and concise summary document containing analytical summary and comments, methodology, raw data, working solution scheme and representative chromatography

‍About our Tier 1 – Discovery bioanalytical services

‍Quick and simple, our Discovery option aims to generate robust data using generic, tried-and-tested methodologies to quantify your compound and provide rapid, informative data on which decisions can be made. This tier involves no commitment to method development, making it ideal as a follow-on from our PK screening option, or for compounds from familiar chemical series likely to run well under industry-standard bioanalytical conditions. With our Discovery offering, we minimize costs while maintaining our characteristic exacting standards, enabling you to submit more compounds in less time, accelerating lead identification efficiently and affordably. Reporting options are available, from simple data tables to formal written data reports, with the flexibility to tailor documents to your requirements.

‍What does Tier 1 – Discovery consist of:

• Compound optimization under industry-standard conditions (MS and LC)
• Sample extraction (protein precipitation) 
• Inclusion of generic internal standards
• Data processing:
  • concentration data

• PK parameter interpretation available at request Reporting

Find out more about our the other tiers

• PK screening: a cost-effective option for optimization and compatibility testing of your compound, using minimal material and reducing animal usage
• Tier 2 - Discovery+: enhanced bioanalysis with method development for your discovery projects, prioritizing specificity, speed and high-quality results
• Tier 3 - Discovery+ Customized: is a customized bioanalytical service for clients needing tailored methods and willing to invest time and resources into method development and robustness testing
• Tier 4 - Scientific Validation: supports in vitro projects and early-stage non-regulated/non-clinical/clinical analyses, offering method validation in addition to standard services, with separate studies for development, validation, and analysis, and optional QA audits
• Tier 5 - Full Validation: supports non-clinical GLP and clinical GCP projects, conducting validations per industry guidelines with separate method development, validation, and analysis studies, including optional QA audits, long-term stability assessments, and incurred sample reanalysis (ISR) for pivotal trials

Find out how we can help you rapidly evaluate the PK of your therapeutic and have a confidential discussion with our experts about your project needs.