Synthetic Chemistry

Synthetic chemistry plays a pivotal role in successful drug discovery programs. Designing elegant and efficient syntheses to access new chemical entities requires in-depth expertise and cutting-edge technologies.

For over 25 years, our chemists have deployed their considerable expertise in synthesis to access unchartered chemical space and enable SAR investigations critical to our clients’ drug discovery projects.

Fast-track drug discovery with high-end synthetic chemistry services

• > 80% of our chemists are PhD educated and have on average > 10 years’ industry experience
• We have a proven track record of delivering innovative syntheses with > 50 peer reviewed articles and patents authored in the last 10 years
• Our synthetic expertise spans a wide range of chemistries including small molecules, nucleosides, peptides, carbohydrates, macrocycles and lipids
• We enable SAR exploration in traditional small molecule drug discovery and novel therapeutic modalities (e.g. PROTACs, ProTides, prodrugs, ADCs and covalent drugs) by the efficient synthesis of targets and their structurally related derivatives
• We work in concert with drug hunters across our discovery services and are responsive to constantly evolving project needs
• As your project reaches key development milestones, we seamlessly transition know-how and technologies from discovery chemistry through to kilo-scale GMP and non-GMP manufacture

We offer flexible synthetic chemistry services adapted to your needs, either standalone or fully integrated with our drug discovery services, from concept to clinic. 

Innovative synthetic chemistry solutions

Our state-of-the-art chemistry platform empower our chemists to innovate with synthetic solutions adapted to your projects:

• Parallel synthesis and purification for lean SAR scouting
• Photochemistry and electrochemistry to unlock challenging synthetic routes
• Flow chemistry and hazard evaluation to increase process safety
• Design of Experiment (DoE) for immediate enhancement of yield and purity
• Solid-phase peptide synthesis 
• High pressure chemistry to facilitate hydrogenation and carbonylation
• A multi-reactor crystallizer and automated chromatography systems streamline development of isolation protocols
• Thermal hazard screening

Our laboratories are equipped with a comprehensive suite of instruments to analyze, purify and characterize chemical matter, with additional expertise provided by our dedicated analytical chemistry team:

• 3 open-access 400 MHz NMRs
• UPLC/MS and GC/MS suites
• Mass Directed AutoPurification
• Analytical and semi-preparative chiral Supercritical Fluid Chromatography (SFC) 

We pride ourselves in being at the forefront of data quality, integrity and security. All our experiments are integrated into our Scilligence ELN platform, enabling the seamless transfer of information between scientific disciplines within a project.