Interaction Analysis

Our biophysical sciences team use a variety of techniques to perform comprehensive interaction studies across various therapeutic modalities: 

• Binding affinity, thermodynamic, stoichiometric, and kinetic measurements 
• Target selectivity and specificity evaluation 
• Protein-protein interactions and complex formation analysis  

Modality-agnostic interaction analysis 

We offer tailored interaction analysis for different therapeutic modalities to understand binding kinetics and affinity to target macromolecules (e.g., nucleic acids or proteins). These include small molecules, antibodies, ADCs and TPDs (e.g. PROTACS and molecular glues).  

We can also assess binary and ternary complex formation using SPR, GCI and ITC. Importantly, interaction analysis data can also reveal insights into binding stoichiometry and specificity, which is important for understanding potential off-target effects. Epitope mapping can also be achieved in a high-throughput manner using SPR and GCI.  

Advancing drug discovery through interaction analysis 

Our interaction analysis capabilities help our clients: 

• Strengthen target validation: Providing concrete evidence of target engagement and mechanism of action 
• Enhance hit finding and screening data: By combining interaction analysis readouts with activity analysis, we ensure only fully validated hits enter the hit-to-lead process, saving both time and money by avoiding false positives 
• Accelerate lead optimization: Rapidly identify and prioritize promising candidates based on their biophysical properties 

By leveraging our extensive expertise and advanced instrumentation, the biophysical sciences team can design custom workflows to support effective translation of diverse therapeutic modalities from early drug discovery to candidate selection. Our comprehensive approach ensures thorough assessment of interaction analysis, enabling informed decision-making throughout the drug discovery process.