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In vivo ADME & DMPK
High-quality in vivo Pharmacokinetics plays a pivotal role in the development of safe and efficacious drugs. At Concept Life Sciences, our DMPK experts develop impactful in vivo PK studies, then gather and interpret data to help make informed decisions to steer your project to success.
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Our in vivo ADMET & DMPK capabilities
Our DMPK experts and bioanalyst work with trusted partners to offer non-GLP in vivo PK services in mice and rats.
- Bioanalytical method development and validation
- Highly flexible study design and readouts
- Formulation studies
- Highly flexible dosing routes
- Array of sampling techniques & matrices
- Determination of PK parameters
DMPK consultancy
We provide expert DMPK guidance throughout the drug discovery process, and work in concert with our medicinal chemistry and biology experts to steer your project towards the clinic.
- Define purposeful screening cascades adapted to each project
- Interpret in vitro and in vivo ADMET data and identify correlations to guide discovery efforts
- Recommend dosing regimens to drive target engagement and efficacy with PK/PD modelling
- Predict human PK profiles with PBPK and allometric modelling