Spatial Biology

How cells and molecules organise and interact within the context of the tissue environment is central to many complex biological processes, including disease progression and drug response. It is therefore crucial to study these processes within an intact tissue environment. This can be achieved using techniques that enable the visualisation and quantification of multiple biomolecules, such as RNA and protein, in situ at a single-cell level.

In recent years the spatial biology field has taken huge strides forward, with techniques such as multiplex immunofluorescence staining, RNAscope, and spatial transcriptomics and proteomics permitting spatial phenotyping of cells across whole tissue. These techniques can be used to drive forward drug discovery by aiding with target validation, biomarker assay development, target screening, and enhancing our understanding of drug response and mechanism of action.

We offer a range of spatial biology services to capture the varying requirements throughout the drug discovery journey.

Histology

Our Histology team utilise the latest laboratory equipment and cutting-edge technologies to provide an end-to-end, GCP-compliant histology service from tissue sourcing and processing through to tissue staining and whole slide imaging. Key services include bespoke multiplex immunofluorescence staining and RNAscope.

Image Analysis

A fully integrated image analysis service compatible with each of our Histology assays. We use Visiopharm, an AI-driven precision pathology software.

Spatial Transcriptomics and Proteomics

We offer a range of spatial transcriptomics and proteomics solutions through use of the 10X Visium Spatial Gene Expression Assay and Nanostring GeoMx platform.

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