Cell Lines

We have extensive experience of culturing a broad variety of  cell lines, and can offer:

•     Instant access to a diverse inventory of cell lines  representing various cancers and tissues (e.g., skin, lung, liver, pancreas,  brain).
•     Ability to source cell lines from commercial vendors based on  project requirements.

We offer expertise in tissue culture  and assay design:

•    Skilled tissue culture and cell biologist experts to design,  conduct, and interpret assays using selected methodologies and  instrumentation.
•     Proficient handling of multiple cell lines concurrently, ideal  for substantial projects when your team's capacity is limited.

Examples of work conducted using  cell lines:

• Compound impact and transcriptomics  analysis: Assessing compound effects on cell viability, apoptosis, and  proliferation, coupled with downstream transcriptomics analysis, beneficial  for drug repositioning studies.
•    Evaluation in 3D spheroid cultures:  Comparing novel therapies in 3D spheroid cultures versus 2D cultures for more  accurate in vivo efficacy modelling.
•     Immuno-oncology assays:  Assessing compounds for direct and indirect impacts on cancer cell growth and  metastasis through T cell and NK cell-mediated tumour cell killing,  efferocytosis, and phagocytosis.
•   Cell migration assessment:  Evaluating compound impact on cell migration using assays mimicking cancer  metastasis and skin epithelization, like the Epithelial to Mesenchymal  Transition assay.
•    Genetic manipulation for target  validation: Performing genetic manipulation to express or knock down targets  for validation studies.
•    CNS function and disease modelling:  Utilizing CNS cell lines to assess candidate therapeutics for their ability  to modulate neuroinflammatory responses, functional phenotypes and  disease-associated phenotypes.  

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