Bionow Technical Service Award Finalists

Innovation is more than a word at Concept Life Sciences, it’s a promise to our clients that we will pursue technical advances which accelerate their drug discovery.

Therefore, we are delighted to shortlisted for the Bionow Technical Service Award with our industry-leading hit identification platform BioPALS.

Hit identification is a crucial stage of any drug discovery project yet is commonly associated with cost and time intensive techniques. High throughput screening (HTS), DEL screening or scaffold hopping, which require assay development adapted to each campaign, can take months and cost hundreds of thousands.

The development of our proprietary platform BioPALS provides an end-to-end solution, transforming the hit identification paradigm.  

A cutting-edge Machine Learning algorithm enables the triaging of over a billion compounds in a matter of days and the determination of hit binding topologies. Virtual hits are subsequently confirmed in vitro using an orthogonal biophysical screening process combining GCI, DSF and NMR, as well as ADMET profiling.  

BioPALS results in fully characterized, high-quality hits with binding affinities and kinetics, plus ADMET parameters that are:

• Delivered in 6 weeks – 3x faster than traditional hit identification strategies

• 10x cheaper than HTS

Dr Thomas Pesnot, Drug Discovery Services Director at Concept Life Sciences commented:

“This award shortlisting acknowledges our multi-disciplinary team’s ongoing commitment to provide clients with truly innovative technologies that make a tangible difference to the progress of their projects.  

I’m particularly pleased that BioPALS is not only innovative in technology but affordable. It breaks down a major barrier in hit identification for biotechnology companies in particular, especially those in the start-up phase.

I’d like to thank colleagues in biology, chemistry and ADMET for their considerable efforts in making this platform a reality.”  

The Bionow Awards take place on Thursday 6 March at the Concorde Conference Centre, Manchester.

We look forward to meeting nominees across all categories for what we are sure will be an exciting evening celebrating the best of the life science industry's ingenuity and dedication.

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